Chemokines in cardiac fibrosis
R Li, NG Frangogiannis - Current opinion in physiology, 2021 - Elsevier
… migration through CXCR3-independent effects that may involve proteoglycans (Neut, … may
directly stimulate fibroblast activation [41], in mouse cardiac fibroblasts, CCL2 stimulation had …
directly stimulate fibroblast activation [41], in mouse cardiac fibroblasts, CCL2 stimulation had …
Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases
… CXCL10 may have effects on cardiac fibroblasts relevant to wound healing post-MI via
both CXCR3 and proteoglycans… -fibrotic actions of CXCL10 in the heart are CXCR3-independent. …
both CXCR3 and proteoglycans… -fibrotic actions of CXCL10 in the heart are CXCR3-independent. …
[HTML][HTML] The CXCL10/CXCR3 axis and cardiac inflammation: implications for immunotherapy to treat infectious and noninfectious diseases of the heart
… [54] on whether myocardial CXCL10 is harmful or beneficial … reprograming, activation of
cardiac fibroblasts, interstitial and … - and CXCR3-independent,” Immunology, vol. 129, no. 2, pp. …
cardiac fibroblasts, interstitial and … - and CXCR3-independent,” Immunology, vol. 129, no. 2, pp. …
[HTML][HTML] CXCR3 regulates CD4+ T cell cardiotropism in pressure overload–induced cardiac dysfunction
N Ngwenyama, AM Salvador, F Velázquez, T Nevers… - JCI insight, 2019 - ncbi.nlm.nih.gov
… We demonstrate that cardiac fibroblasts and cardiac myeloid … increase in the number
of LV myocardial CXCR3 + CD4 + T … effect of CXCL10 after MI was through CXCR3-independent …
of LV myocardial CXCR3 + CD4 + T … effect of CXCL10 after MI was through CXCR3-independent …
[HTML][HTML] Overview of the mechanisms that may contribute to the non-redundant activities of interferon-inducible CXC chemokine receptor 3 ligands
M Metzemaekers, V Vanheule, R Janssens… - Frontiers in …, 2018 - frontiersin.org
… GAGs are polysaccharides usually present as part of proteoglycan … CXCL10 after
myocardial infarction and inhibition of cardiac fibroblast migration manifest in a CXCR3-independent …
myocardial infarction and inhibition of cardiac fibroblast migration manifest in a CXCR3-independent …
Adding insult to injury-Inflammation at the heart of cardiac fibrosis
… cells modulating fibroblast function, cardiac fibroblasts are … protein components of the
myocardium during homeostasis, … fibrotic actions of CXCL10 operate through CXCR3-independent …
myocardium during homeostasis, … fibrotic actions of CXCL10 operate through CXCR3-independent …
Paired box 6 inhibits cardiac fibroblast differentiation
Y Feng, M Li, S Wang, W Cong, G Hu, Y Song… - Biochemical and …, 2020 - Elsevier
… Pax6 knockdown in CFs decreased CXC chemokine 10 (CXCL10… the predominant cell type
within the myocardium. Various … into the infarcted or hypertrophic regions of a stressed heart, …
within the myocardium. Various … into the infarcted or hypertrophic regions of a stressed heart, …
[HTML][HTML] Potential therapeutic manipulations of the CXCR3 chemokine axis for the treatment of inflammatory fibrosing diseases
MK Groover, JM Richmond - F1000Research, 2020 - ncbi.nlm.nih.gov
… domain plays no role in CXCL10 or CXCL11 binding or ligand-mediated internalization, but
this … in myocardium, which required CXCL10 fibroblast responses through proteoglycans 69 , …
this … in myocardium, which required CXCL10 fibroblast responses through proteoglycans 69 , …
Tissue transglutaminase induction in the pressure-overloaded myocardium regulates matrix remodelling
AV Shinde, M Dobaczewski, JJ De Haan… - Cardiovascular …, 2017 - academic.oup.com
… overload induced through transverse aortic constriction. Moreover, we used isolated
cardiac fibroblasts and macrophages to dissect the mechanisms of tTG-mediated actions. tTG …
cardiac fibroblasts and macrophages to dissect the mechanisms of tTG-mediated actions. tTG …
Fibroblasts in the infarcted, remodeling, and failing heart
C Humeres, NG Frangogiannis - JACC: Basic to Translational Science, 2019 - jacc.org
… In the developing myocardium, cardiac fibroblasts have been … During the 3 phases of infarct
healing, cardiac fibroblasts … protein–10/CXCL10, may inhibit fibroblast migration, serving …
healing, cardiac fibroblasts … protein–10/CXCL10, may inhibit fibroblast migration, serving …